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Where you are

Refractory or multiply relapsed

When standard treatments have been exhausted, the options to ask about include cellular therapies, newer agents, and access pathways for drugs outside a trial. A virtual tumor board can also bring more specialists to a complex case. Here's where to start.

Trials to discuss with your care team

A starting set for this stage, pulled live from ClinicalTrials.gov. Whether any fits is a conversation for your care team.

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Where to start

A free expert panel reviews your case

MIB Agents (TURBO tumor board)

Ask your oncologist to submit your case. A panel of osteosarcoma specialists reviews it together and weighs in — free.

Help getting a drug that isn't in a trial

FDA Project Facilitate

Your oncologist calls them for step-by-step help requesting an investigational drug outside a trial (this is called “expanded access”). Most single-patient requests are approved.

Free help finding trials

NCI Cancer Information Service

You call, and trained specialists search the national trial database for your situation and email you matches. Free.

Questions to bring to your care team

  1. If we've run out of standard options, would expanded access (compassionate use) be worth pursuing? Have you used FDA Project Facilitate?
  2. Would our case be a good candidate for a virtual tumor board review?
  3. Are there cellular-therapy or early-phase trials you'd consider, even if we'd have to travel?

Save trials as you browse — they'll appear on your appointment prep sheet with these questions, ready to print.